ethyl 2-(3-chloro-5-fluorophenyl)cyclopropane-1-carboxylate - Names and Identifiers
ethyl 2-(3-chloro-5-fluorophenyl)cyclopropane-1-carboxylate - Introduction
ethyl 2-(3-chroo-5-fluorophenyl) cyclopropane-1-carboxylate is an organic compound. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: colorless liquid
-Molecular formula: C12H11ClFNO2
-Molecular weight: 255.67g/mol
-Melting point:-20 ℃
-Boiling point: 112-114 ℃
-Density: 1.33g/cm³
Use:
ethyl 2-(3-chroo-5-fluorophenyl) cyclopropane-1-carboxylate has many applications in drug synthesis and organic synthesis.
-Drug synthesis: It can be used as an intermediate for the synthesis of drugs such as anti-inflammatory drugs, analgesics and antiepileptic drugs.
-Organic synthesis: It can be used as a starting material or intermediate for the synthesis of other compounds, and is used for the reaction of organic synthesis.
Method:
The universal method includes the following steps:
1. Through chlorination reaction, fluorine and chlorine atoms are introduced between 3-chloro-5-fluorobenzaldehyde and ionic Cadmium bromide to produce 3-chloro-5-fluorophenyl bromide.
2. The reaction will be bright with hydrogen reduction.
3. The resulting 3-chloro-5-fluorophenylpropene is reacted with ethanone to form 2-(3-chloro-5-fluorophenyl) cyclopropane -1-one.
4. Finally, 1-ketone is reacted with ethyl acetate by esterification to obtain ethyl 2-(3-chloro-5-fluorophenyl) cycloconjugate -1-carboxylate.
Safety Information:
Specific safety information regarding this compound requires further research and understanding. In handling and use, it is necessary to follow safe operating procedures. Because the compound may be toxic and irritating, appropriate protective equipment, such as laboratory gloves and goggles, should be worn. At the same time, avoid inhalation, ingestion or direct contact with the skin.
Last Update：2024-04-09 21:54:55